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Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)

Patients may begin to notice effects on appetite and blood sugar levels within a few weeks, with more significant changes occurring over 2 to 3 months

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